UK Meningitis

Over the past several decades, the incidence of bacterial meningitis in children has decreased but there remains a significant burden of disease in adults, with a mortality of up to 30%. UK Meningitis was a study of 1,126 adult patients aged 16 or over with suspected meningitis enrolled between September 2011 and September 2014 at 42 hospitals across England. The study showed that viruses are the major cause of meningitis in adults in the UK, and impose a considerable clinical burden, both acutely and longer term. To improve management and reduce costs, there is a pressing need for better diagnostic practices, including rapid tests Acute bacterial meningitis in adults. and the delivery of high-quality viral diagnostics locally. Treatments also need to be developed and assessed that could allow quicker recovery and fewer longer-term health consequences.

For further information please visit: www.braininfectionsuk.org/ukmeningitis/

uk meningitis
Patients Recruited
1870

Key Contacts

Role Name Email Telephone
NIHR Doctoral Research Fellow Dr Fiona McGill Fiona.McGill@liv.ac.uk 0151 795 9606
Data Manager Kieran Crabtree Kieran.Crabtree@liv.ac.uk 0151 795 9670


Publications

McGill F, Heyderman RS, Panagiotou S, Tunkel AR, Solomon T. Acute bacterial meningitis in adults. Lancet. 2016 Dec 17;388(10063):3036-3047. doi: 10.1016/S0140-6736(16)30654-7. Epub 2016 Jun 2. PMID: 27265346.

McGill F, Griffiths MJ, Bonnett LJ, Geretti AM, Michael BD, Beeching NJ, McKee D, Scarlett P, Hart IJ, Mutton KJ, Jung A, Adan G, Gummery A, Sulaiman WAW, Ennis K, Martin AP, Haycox A, Miller A, Solomon T; UK Meningitis Study Investigators. Incidence, aetiology, and sequelae of viral meningitis in UK adults: a multicentre prospective observational cohort study. Lancet Infect Dis. 2018 Sep;18(9):992-1003. doi: 10.1016/S1473-3099(18)30245-7. Epub 2018 Jun 29. PMID: 30153934; PMCID: PMC6105576.

McGill F, Griffiths MJ, Bonnett L, Geretti AM, Michael BD, Beeching NJ, McKee D, Scarlett P, Hart IJ, Mutton K, Jung A, Adan G, Gummery A, Sulaiman WAW, Ennis K, Martin A, Haycox A, Miller A, Solomon T, on behalf of the UK Meningitis Study Investigators. Viral meningitis in UK adults - a multicentre prospective observational cohort study of incidence, aetiology and sequelae Lancet Infect Dis 2018; 18: 992-1003

McGill F, Griffiths MJ, Solomon T. Viral meningitis: current issues in diagnosis and treatment. Curr Opin Infect Dis. 2017 Apr;30(2):248-256. doi: 10.1097/QCO.0000000000000355. PMID: 28118219.

Griffiths MJ, McGill F, Solomon T. Management of acute meningitis. Clin Med (Lond). 2018 Mar;18(2):164-169. doi: 10.7861/clinmedicine.18-2-164. PMID: 29626023; PMCID: PMC6303447.