Welcome to the BASICS Trial Website
The BASICS Trial is a study to determine whether antibiotic or silver impregnated VP shunts reduce early infection (within 6 months) compared to standard VP shunt in hydrocephalus following insertion of de novo shunt.
Background & Aim
Two new devices have
been introduced to try to reduce shunt infection;
antibiotic-impregnated (Bactiseal) and
silver-impregnated (Silverline)
shunts. This study will compare these new shunts to
standard shunts in a study called a randomised
multi-centre controlled trial.
This will
be a national trial recruiting 1600 participants from
specialist neurosurgical units. Our goal is to establish
which VPS provides most protection against infection and to
ensure standardisation of care and infection
rates across the country
Recruitment status
| Site | Recruitment |
| Alder Hey Children's Hospital | 119 |
| The Walton Centre | 155 |
| Southampton General Hospital | 175 |
| Leeds General Infirmary | 92 |
| Queens Medical Centre-Nottingham | 141 |
| Royal Manchester Children's Hospital | 48 |
| Great Ormond Street Hospital | 71 |
| Salford Royal Hospital | 82 |
| Addenbrookes Hospital | 85 |
| Sheffield Children's Hospital | 42 |
| Royal Hallamshire Hospital | 22 |
| University Hospital of Wales-Cardiff | 129 |
Birmingham Children's Hospital |
30 |
| Bristol | 188 |
| Kings College Hospital | 36 |
| Royal Sick Children's Hospital-Edinburgh | 8 |
| Western General Hospital- Edinburgh | 5 |
| James Cook Hospital | 22 |
| Children's University Hospital Dublin | 69 |
| The National Hospital, Queens Square | 73 | The Royal Victoria Infirmary, Newcastle | 14 |
| Total recruitment | 1606 |
| Table last updated 8th February 2018 |
